Diabetes and hypertension: Pivotal involvement of purinergic signaling

CR1 genotype and haplotype involvement in coronary artery disease: the pivotal role of hypertension and dyslipidemia.

Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and coronary syndromes. Atherosclerosis is a complex multifactorial disorder. Data indicate that the complement proteins play a crucial role in the link between inflammation and atherogenesis. Thus, there is evidence supporting the role of complement activation in atherogenesis. Complement receptor 1 (CR1) is a membrane pr...

Prevalence of Hypertension and Diabetes in Elderly Residents of Kahrizak

Objectives: The aim of the present study was to investigate the prevalence of hypertension and type II diabetes in elderly Iranianresidents of the Kahrizak Charity Foundation (KCF). Methods & Materials: In this cross-sectional study, a total of two hundred sixty eight men and women ≥60 years were studied. The data were collected during annual health examination of the elderly residents in KC...

Purinergic Signaling in Bone

1 Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, 2600 Glostrup, Denmark 2Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy 3 Bone Biology Laboratory, Department of Cell and Developmental Biology, University College London, London WC...

The Pivotal Role of mTORC2 and Involvement of Ribosomal Protein S6 in Cardioprotective Signaling

Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.

RATIONALE There is tight coupling between Akt activation and suppression of cell death. Full Akt activation requires mammalian target of rapamycin complex 2 (mTORC2), but the regulation of mTORC2 is unclear. OBJECTIVE To gain new insights into mechanisms of mTORC2/Akt signaling. METHODS AND RESULTS The role of mTORC2 in cardioprotection was examined. In perfused mouse hearts, ischemic preco...